Expand Menu

Explore Faculty & Staff Academics Research Admissions Students Examination

Collapse Menu

Project
ICMR ADHOC Project sanctioned to SIU

Project Title : SNP and Expression of Genes involved in Metabolism of Polyunsaturated fatty acids of Pregnant Women and their Association with Neonate Anthropometrics

Research Grant received from ICMR, New Delhi, (Ref-5/9/68/2008-RHN) with the release of first installment of the grant Rs. 7,01,3701 to SIU

Duration : 2 years

Principle Investigator : Dr. Kalpana Joshi, Professor and Director, Symbiosis School of Biomedical Sciences, Symbiosis International University, Pune Co-Investigators: Dr. Anand Pandit, Head, Dept. of Pediatrics, Dr. Otiv, Dept. of Obstetrics and Gynecology, King Edward Memorial Hospital (KEM), Pune

Summary of the project : There is ample evidence that long chain polyunsaturated fatty acids (LCPUFA) nutrition influences pregnancy outcome and neonatal anthropometrics. LCPUFA include the dietary essential fatty acids namely n-6 and n-3 fatty acids and their long chain polyenes namely arachidonic acid (AA) and docosahexanoic acid (DHA) which are synthesized de novo from the dietary essential fatty acids. The enzymes ∆6 desaturase, ∆5 desaturase and elongase are the key enzymes involved in this metabolic pathway. These enzymes are encoded by the genes namely FADS1, FADS2, ELOVL2 respectively. The specific aim of the proposed research is to study the single nucleotide polymorphism and gene expression of these genes in pregnant women and their association with neonatal anthropometrics. The study would also help determine the association of the dietary PUFA consumption and expression of these genes. An association observed would help in determining the need for supplementation of the essential fatty acids during the course of pregnancy in women with observed gene polymorphism.








^ Back to Top

Photo Gallery

   360o Campus Tour